Anticholinergics and Amantadine are used early for mild Parkinson disease symptoms; used later as adjunct therapy for the movement side effects caused by levodopa.
Anticholinergics work by blocking muscarinic receptors in the brain, helping balance cholinergic activity and reduces tremors.
Amantadine is an antiviral used for influenza, inhibits the reuptake of dopamine into the synaptic cleft and stimulate more dopamine receptors.
Common side effects include anxiety, confusion/memory impairment, drowsiness, dry nose and mouth, blurred vision, constipation, fast-heart beat, and difficulty urinating; decrease sweating, increased likelihood of heatstroke.
Patients should avoid alcohol because of the intensifying effect to drowsiness and confusion; patients should drink plenty of fluids and eat foods high in fiber.
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